PMID: 6167283Jul 1, 1981Paper

Zinc transport proteins in plasma

The British Journal of Nutrition
J K Chesters, M Will

Abstract

1. Both albumin and transferrin have been suggested as carriers of zinc in plasma. Their relative importance in Zn transport was therefore investigated as a preliminary to a study of the rates of passage of Zn through plasma. 2. The apparent log stability constant for Zn binding to human apotransferrin at pH 7.4 was estimated to be approximately 5.9 which is substantially lower than previous reports of 7.0 for the corresponding value for Zn binding to albumin (Giroux & Henkin, 1972). 3. When the relative abilities of human albumin and apotransferrin to compete for Zn with low-molecular-weight chelators were compared at the same relative concentrations of these proteins as are found in plasma, albumin retained substantially more Zn then transferrin. 4. It seems likely that albumin acts as the major transport protein for Zn in plasma of most species, Zn also being present firmly bound to alpha 2-macroglobulin. 5. In porcine plasma or serum however, there were three major Zn-binding proteins, two of which were probably albumin and alpha 2-macroglobulin. The nature of the third component remains unknown but it appeared to have a molecular weight of between 1000000-14000000, it was precipitated by 2.2 M-ammonium sulphate and by 150 ...Continue Reading

References

Apr 1, 1975·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·D Scott, G H McIntosh
Dec 14, 1979·Biochimica Et Biophysica Acta·P A Charlwood
Apr 1, 1977·The British Journal of Surgery·T Hallböök, H Hedelin
Nov 13, 1976·The Veterinary Record·W CorrigallR B Williams
Oct 27, 1975·Biochemical and Biophysical Research Communications·G W Evans, T W Winter
Apr 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·G W Evans
Feb 1, 1974·Biochemical Medicine·A K NandedkarF Friedberg
Jun 26, 1972·Biochimica Et Biophysica Acta·E L Giroux, R I Henkin
Jan 1, 1972·Archives of Biochemistry and Biophysics·B Nagy, S S Lehrer
Mar 17, 1970·Biochemistry·K G MannC Tanford
Jun 9, 1970·Biochemistry·A F Parisi, B L Vallee

❮ Previous
Next ❯

Citations

Dec 8, 2019·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Ammar M EbrahimBernhard Michalke
Sep 16, 1991·Klinische Wochenschrift·A Maldonado MartínJ de Dios Luna del Castillo
Sep 11, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Shawn A ManleyJürgen Gailer
Jun 6, 2009·Expert Review of Proteomics·Shawn A Manley, Jürgen Gailer
Apr 17, 2015·Neural Plasticity·Guillermo VelaAndreas M Grabrucker
Jul 9, 2020·Metallomics : Integrated Biometal Science·Kaj SullivanT Kurt Kyser
May 1, 1991·The British Journal of Nutrition·N M LoweM J Jackson
Jul 1, 1993·The British Journal of Nutrition·S J Fairweather-TaitP C Croghan
Jul 19, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Koichi Orino
Jan 1, 1990·Biological Trace Element Research·H FaureJ Arnaud
Sep 1, 1984·Journal of Clinical Pathology·J W Foote, H T Delves
Apr 1, 1995·Aging : Clinical and Experimental Research·N Fabris, E Mocchegiani
Jan 14, 2017·Inflammopharmacology·Magdalena JaroszTadeusz Librowski
Jun 19, 2015·Journal of Clinical Pathology·Andrew DuncanIan Morrison
Sep 12, 2014·Metallomics : Integrated Biometal Science·A RomeoE Doelsch
Jul 1, 2020·Biochimica Et Biophysica Acta. General Subjects·François Foulquier, Dominique Legrand
Dec 1, 1983·Immunology Today·J H Brock, T Mainou-Fowler
Aug 3, 2021·Metabolism Open·Mary Barbara, Ayse L Mindikoglu
Aug 10, 2021·Scandinavian Journal of Clinical and Laboratory Investigation·Louise H JørgensenPhilippe Grandjean

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.