Zingerone prevents lead-induced toxicity in liver and kidney tissues by regulating the oxidative damage in Wistar rats.

Journal of Food Biochemistry
Insha AminParvaiz Ahmad

Abstract

Among the heavy metal poisonings, lead is considered as a major toxic metal causing hematological, neurological, immunological, hepatic, and renal dysfunctions. Lead causes inhibition of ALAD leading to the ALA accumulation inside the cells. Lead also leads to disruption of the anti-oxidative enzyme system, organ function, and lipid membranes of the cell causing oxidative stress. Zingerone, a phenolic alkanone, is an active edible ingredient present in the ginger that possess varied pharmacological properties. The aim of our study was to evaluate the protective effect of zingerone in lead-induced toxicity in wistar rats. ALAD concentration was improved in kidney and liver tissues treated with zingerone. Protective effect of zingerone was observed in terms of significant improvement in kidney and liver histology, anti-oxidant enzyme activity (CAT, SOD, GPx, and GR), organ function parameters, lipid profile, and decreased level of LPO. Therefore, zingerone pretreatment can be a promising agent for alleviation of lead-induced oxidative damage in cells. PRACTICAL APPLICATIONS: Published reports have revealed that consumption of certain bioactive nutrients for example, flavonoids, mineral elements, and vitamins can offer defense fro...Continue Reading

References

Apr 1, 1979·The American Journal of Physiology·A J VanderB Johnson
Feb 1, 1981·Archives of Biochemistry and Biophysics·J R WrightP R Miles
Jul 25, 1997·The Journal of Biological Chemistry·I Fridovich
Oct 26, 2006·Kidney International·E B EkongV M Weaver
Aug 2, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Li-Kun HanMasato Saito
Dec 6, 2008·Chemico-biological Interactions·Oladipo AdemuyiwaJai Raj Behari
Apr 7, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·O AdeyemiE A Adebayo
May 5, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·J Renugadevi, S Milton Prabu
Mar 10, 2010·Experimental Gerontology·Mi Kyung KimHae Young Chung
Feb 22, 2011·European Journal of Pharmacology·Bhuvanagiri Nageshwar RaoBola Sadashiva Satish Rao
Feb 18, 2012·Metallomics : Integrated Biometal Science·Ebany J Martinez-FinleyMichael Aschner
May 1, 2001·Current Protocols in Toxicology·H Fujita
Nov 3, 2012·Interdisciplinary Toxicology·Gagan FloraArchana Tiwari
Jan 2, 2013·Indian Journal of Clinical Biochemistry : IJCB·Ambica P JangidPraveen Sharma
Mar 30, 2013·Environmental Toxicology and Pharmacology·Anna Winiarska-Mieczan
Jan 1, 2012·Asian Pacific Journal of Tropical Biomedicine·Nabil M IbrahimYasmin E Abdel-Mobdy
Aug 2, 2013·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Rajenderan VinothkumarNamasivayam Nalini
Aug 13, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·You Yeon ChoiWoong Mo Yang
Sep 6, 2013·Biological Trace Element Research·Iyappan RajanP R Manish Kumar
Dec 18, 2013·Drug and Chemical Toxicology·Manoj Kumar VelagaBettaiya Rajanna
May 8, 2014·Journal of Food Science and Technology·Y Amarnath ReddyP Indira
May 16, 2014·Biological Trace Element Research·Gamaleldin I Harisa
Feb 15, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Vesna MatovićZorica Bulat
May 8, 2015·Biological Trace Element Research·Ashraf M Abdel-MoneimIsmail A Sadek
Jun 25, 2015·TheScientificWorldJournal·Bilal AhmadManzoor ur Rahman Mir
Feb 13, 2016·Redox Report : Communications in Free Radical Research·Parisa HasaneinIraj Khodadadi
Jul 12, 2016·Veterinary World·Mohammed Abdulrazzaq AssiMohd Ali Rajion
Oct 28, 2016·Environmental Science and Pollution Research International·V Manoj KumarB Rajanna
Nov 20, 2016·Environmental Toxicology and Pharmacology·Cássia Regina Bruno NascimentoClaudia Bueno Dos Reis Martinez
Jan 1, 2010·The Libyan Journal of Medicine·Arti SharmaLeena Kansal
Feb 15, 2017·Journal of Complementary & Integrative Medicine·Jawhar LaamechBadiaa Lyoussi
Mar 30, 2017·Frontiers in Pharmacology·Samuel J OfforOrish E Orisakwe
Apr 28, 2017·The Journal of Nutrition, Health & Aging·A MeramatR A Sharif

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Citations

Nov 8, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Adil Farooq WaliAjaz Ahmad
Jan 18, 2022·Biological Trace Element Research·Jerome Ndudi AsiweBuduchim Rejoice Buduburisi

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