PMID: 8889408Oct 1, 1996Paper

Zipeprol: preclinical assessment of abuse potential

Drug and Alcohol Dependence
M D ActeoW L Woolverton


Zipeprol was evaluated in a number of in vitro and in vivo assays predictive of stimulant, depressant, or opioid abuse potential. Zipeprol had affinity for mu and kappa opioid binding sites as well as sigma binding sites. However, it failed to exert opioid-like agonist actions in rodents, and did not attenuate withdrawal signs in morphine- or pentobarbital-dependent rats. Zipeprol did not substitute for either amphetamine or pentobarbital in drug discrimination assays in rhesus monkeys. On the other hand, it suppressed morphine withdrawal signs in rhesus monkeys in two assays, and it acted as a quadazocine-sensitive reinforcer in monkeys trained to self-inject alfentanil. Zipeprol also acted as a reinforcer in monkeys trained to self-inject methohexital. In a dose range of 10-18 mg/kg, zipeprol induced convulsions in monkeys. Zipeprol appears to have abuse potential and a novel spectrum of action involving both opioid and non-opioid effects.


Mar 1, 1977·Pharmacology, Biochemistry, and Behavior·L L CoughenourR B Parker
Mar 1, 1992·Trends in Pharmacological Sciences·R QuirionD P Taylor
Jan 1, 1992·Journal of Substance Abuse Treatment·D SlobodkinC A Jesurun
Mar 1, 1991·Journal of Medicinal Chemistry·R A GlennonJ B Fischer
Jan 1, 1991·Psychopharmacology·M A NaderW L Woolverton
Mar 1, 1991·Drug and Alcohol Dependence·L JaniriE Tempesta
Jun 1, 1990·British Journal of Addiction·E TempestaS Diodato
Oct 1, 1989·Drug and Alcohol Dependence·G WingerJ H Woods
Mar 1, 1985·Pharmacology, Biochemistry, and Behavior·E B Hollingsworth, G A Patrick
Jun 1, 1986·Journal of Pharmacological Methods·L A Dykstra, J H Woods
Jan 7, 1984·Lancet·F Perraro, A Beorchia
Dec 1, 1994·Drug and Alcohol Dependence·W L WoolvertonL S Harris
Jul 1, 1994·Journal of Analytical Toxicology·Y YooM Kim

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