Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro

Cytokine
Thiago DuarteIvana Beatrice Mânica da Cruz

Abstract

Antipsychotic drugs are used to treat schizophrenia and other psychiatric disorders. However, most of these drugs present side effects causing obesity and other serious metabolic alterations that correlate with grade of chronic inflammation. In contrast, ziprasidone's (ZIP) metabolic side effects are attenuated relative to those of other antipsychotic drugs, but some reports suggest that this drug could cause allergic, hypersensitive reactions in susceptible patients. At present, the mechanism of ZIP's effect on peripheral inflammatory metabolism is not well characterized. We conducted an in vitro study to evaluate the effect of ZIP on a macrophage cell line (RAW 264.1). Our results showed that in non-activated macrophage cells, ZIP exposure initiated macrophage spreading; increased cellular proliferation, as evaluated by MTT and flow cytometry assays; and presented higher levels of oxidant molecules involved in the inflammatory response (nitric oxide, superoxide, reactive oxygen species), and proinflammatory cytokines (IL-1, IL-6, TNFα, INFγ). Levels of IL-10, an anti-inflammatory cytokine were lower in ZIP-exposed cells. These effects were less potent than those caused by the positive control for inflammation induction (phyto...Continue Reading

Citations

Jan 30, 2019·PloS One·Marcelo Soares FernandesIvana Beatrice Mânica da Cruz
Sep 8, 2018·Frontiers in Psychiatry·Guillaume FondLaurent Boyer
May 7, 2020·Frontiers in Endocrinology·Samantha Alvarez-HerreraLenin Pavón
Mar 6, 2021·Brain, Behavior, & Immunity Health·R A NolanP J Gaskill
Aug 24, 2019·Cytokine·Patrícia MaurerJacqueline da Costa Escobar Piccoli

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