Ziprasidone-associated pedal edema in the treatment of schizophrenia

Progress in Neuro-psychopharmacology & Biological Psychiatry
Hsiao-Lun KuYuan-Hwa Chou

Abstract

It has been reported that second generation of antipsychotic drugs may induce pedal edema. The purpose of this case report is to demonstrate that the recently marketed antipsychotic drug, ziprasidone induced pedal edema with an increased plasma immunoglobulin E (IgE) level. A 51-year-old female schizophrenic patient who developed severe pedal edema was treated with ziprasidone for 6 weeks. Admission routine data that included biochemical, blood and urine analysis were normal except for the plasma IgE level, which was significantly elevated. Although the pedal edema subsided after discontinuation of ziprasidone and administration of diuretics, the plasma IgE level remained high. This is the first case report attempting to demonstrate the existence of ziprasidone-induced pedal edema in the treatment of schizophrenia. In this case, the pedal edema was associated with an IgE-related allergic reaction.

References

Aug 1, 1975·The Journal of Clinical Endocrinology and Metabolism·O KuchelJ Genest
Nov 4, 1995·BMJ : British Medical Journal·C Cooney, A Nagy
Nov 10, 1994·The New England Journal of Medicine·J C Roujeau, R S Stern
Aug 21, 2003·The Journal of Clinical Psychiatry·Richard C Christensen
Oct 27, 2004·European Psychiatry : the Journal of the Association of European Psychiatrists·Chih-Kang Chen, Yuan-Hwa Chou

❮ Previous
Next ❯

Citations

Aug 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chun-Yen ChenChih-Lun Chen
Jun 24, 2016·Indian Journal of Psychological Medicine·Musa Usman Umar, Aminu Taura Abdullahi
Apr 30, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Erdinc CicekFaruk Uguz
Dec 17, 2009·Australasian Psychiatry : Bulletin of Royal Australian and New Zealand College of Psychiatrists·Nick O'ConnorAbdul Adra
May 7, 2020·Frontiers in Endocrinology·Samantha Alvarez-HerreraLenin Pavón

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Antipsychotic Drugs

Antipsychotic drugs are a class of medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia and bipolar disorder. Discover the latest research on antipsychotic drugs here

Related Papers

European Psychiatry : the Journal of the Association of European Psychiatrists
Chih-Kang Chen, Yuan-Hwa Chou
General Hospital Psychiatry
Kausik RoyRaja Shekhar R Sappati Biyyani
The Journal of Clinical Psychiatry
Richard C Christensen
© 2022 Meta ULC. All rights reserved