Zirconium-89-labelled rituximab PET-CT in orbital inflammatory disease

EJNMMI Research
Kamil G LabanBart de Keizer

Abstract

Orbital inflammatory diseases are a heterogenic group of conditions that often entail a difficult diagnostic process and many patients are treatment resistant. Inflammatory diseases can be visualized by Zirconium-89-labelled rituximab PET-CT (89Zr-rituximab PET/CT). In this study, we describe our experience and possible potential of the 89Zr-rituximab PET/CT for diagnostic and therapeutic management of refractory orbital inflammation. Retrospectively, 89Zr-rituximab uptake was assessed and related to clinical data. The main outcome measures were the characteristics of the scan and the clinical relation of uptake with the diagnostic process and treatment effectivity. Twelve patients with thyroid eye disease (TED) and suspected idiopathic orbital inflammation (IOI) were scanned. Six patients had a strong 89Zr-rituximab uptake and showed a focal distribution within the lesion. Four patients (one TED, three IOI) responded well to rituximab treatment after a positive scan. 89Zr-rituximab PET/CT was essential to the diagnosis of optic nerve meningioma in one patient. 89Zr-rituximab PET/CT has the potential to be a powerful tool for the detection of B cell-mediated disease within the orbit and ocular adnexa. This technique can be a va...Continue Reading

References

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Citations

Nov 20, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Bart de KeizerRachel Kalmann
May 16, 2020·Mediators of Inflammation·Claudia FabianiLuca Cantarini
Aug 7, 2020·Journal of Clinical Medicine·Martha S van GinkelArjan Vissink
Jul 28, 2020·Progress in Retinal and Eye Research·Min Joung LeeJames T Rosenbaum
Apr 4, 2021·Journal of Clinical Medicine·Valeria ManfrèAlen Zabotti
Mar 24, 2020·Chemical Reviews·Weijun WeiWeibo Cai
Aug 28, 2021·Journal of Ophthalmic Inflammation and Infection·Caleb C NgEmmett T Cunningham

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biopsy
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