ZmcrtRB3 encodes a carotenoid hydroxylase that affects the accumulation of α-carotene in maize kernel

Journal of Integrative Plant Biology
Yi ZhouXiaohong Yang

Abstract

α-carotene is one of the important components of pro-vitamin A, which is able to be converted into vitamin A in the human body. One maize (Zea mays L.) ortholog of carotenoid hydroxylases in Arabidopsis thaliana, ZmcrtRB3, was cloned and its role in carotenoid hydrolyzations was addressed. ZmcrtRB3 was mapped in a quantitative trait locus (QTL) cluster for carotenoid-related traits on chromosome 2 (bin 2.03) in a recombinant inbred line (RIL) population derived from By804 and B73. Candidate-gene association analysis identified 18 polymorphic sites in ZmcrtRB3 significantly associated with one or more carotenoid-related traits in 126 diverse yellow maize inbred lines. These results indicate that the enzyme ZmcrtRB3 plays a role in hydrolyzing both α- and β-carotenes, while polymorphisms in ZmcrtRB3 contributed more variation in α-carotene than that in β-carotene. Two single nucleotide polymorphisms (SNPs), SNP1343 in 5'untranslated region and SNP2172 in the second intron, consistently had effects on α-carotene content and composition with explained phenotypic variations ranging from 8.7% to 34.8%. There was 1.7- to 3.7-fold change between the inferior and superior haplotype for α-carotene content and composition. Thus, SNP1343 a...Continue Reading

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Citations

Oct 12, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Raman BabuKevin Pixley
Mar 14, 2012·Journal of Integrative Plant Biology·Martin A J ParryJosé Luis Araus
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Jun 18, 2020·Frontiers in Genetics·Kaliyaperumal AshokkumarThomas D Warkentin
Jul 10, 2020·International Journal of Molecular Sciences·Romesh K Salgotra, C Neal Stewart
Jul 31, 2021·Plant Communications·David B MedeirosAlisdair R Fernie
Jul 24, 2021·Scientific Reports·Dejene KebedeMelaku Gedil
Aug 28, 2021·Journal, Genetic Engineering & Biotechnology·Nazarul HasanRafiul Amin Laskar

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