Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy

Scientific Reports
Xiupeng WangAtsuo Ito

Abstract

Zn-, and Mg-containing tricalcium phosphates (TCPs) loaded with a hydrothermal extract of a human tubercle bacillus (HTB) were prepared by immersing Zn-TCP and Mg-TCP in HTB-containing supersaturated calcium phosphate solutions. The in vitro and in vivo immunogenic activities of the HTB-loaded Zn-, and Mg-TCPs (Zn-Ap-HTB and Mg-Ap-HTB, respectively) were evaluated as potential immunopotentiating adjuvants for cancer immunotherapy. The Zn-Ap-HTB and Mg-Ap-HTB adjuvants showed no obvious cytotoxicity and more effectively stimulated granulocyte-macrophage colony-stimulating factor (GM-CSF) secretion by macrophage-like cells than unprocessed HTB or HTB-loaded TCP (T-Ap-HTB) in vitro. Zn-Ap-HTB and Mg-Ap-HTB mixed with liquid-nitrogen-treated tumor tissue markedly inhibited the in vivo development of rechallenged Lewis lung carcinoma (LLC) cells compared with T-Ap-HTB and the unprocessed HTB mixed liquid-nitrogen-treated tumor tissue. Zn-Ap-HTB and Mg-Ap-HTB contributed to eliciting potent systemic antitumor immunity in vivo.

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Citations

Dec 25, 2015·Colloids and Surfaces. B, Biointerfaces·Xiupeng WangNoriko M Tsuji
Dec 17, 2014·The Journal of Pharmacy and Pharmacology·Charlotte N MaughanGareth R Williams
Feb 26, 2016·Scientific Reports·Yuanhao WuQingshui Yin
Jan 7, 2017·Nature Communications·Xia LiDmitri Golberg
Oct 4, 2016·Expert Review of Vaccines·Jean-Daniel MassonGuillemette Crépeaux
Jul 18, 2017·Expert Review of Vaccines·Yahua LinQinjian Zhao
Jun 19, 2018·Chemical Society Reviews·Xia LiAtsuo Ito
Apr 9, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Natalia AnisimovaYuri Estrin
Mar 19, 2016·Advanced Healthcare Materials·Xiupeng WangAtsuo Ito
Jan 29, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Janin ChandraMeihua Yu
Nov 24, 2018·Colloids and Surfaces. B, Biointerfaces·Xiupeng WangAtsushi Yamazaki

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Datasets Mentioned

BETA
GM-CSF

Methods Mentioned

BETA
dynamic light scattering
ELISA
x-ray spectroscopy
X-ray
infrared spectrometry
PMA

Software Mentioned

ALV
- Correlator

Related Concepts

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