Zn- and Mg- containing tricalcium phosphates-based adjuvants for cancer immunotherapy

Scientific Reports
Xiupeng WangAtsuo Ito


Zn-, and Mg-containing tricalcium phosphates (TCPs) loaded with a hydrothermal extract of a human tubercle bacillus (HTB) were prepared by immersing Zn-TCP and Mg-TCP in HTB-containing supersaturated calcium phosphate solutions. The in vitro and in vivo immunogenic activities of the HTB-loaded Zn-, and Mg-TCPs (Zn-Ap-HTB and Mg-Ap-HTB, respectively) were evaluated as potential immunopotentiating adjuvants for cancer immunotherapy. The Zn-Ap-HTB and Mg-Ap-HTB adjuvants showed no obvious cytotoxicity and more effectively stimulated granulocyte-macrophage colony-stimulating factor (GM-CSF) secretion by macrophage-like cells than unprocessed HTB or HTB-loaded TCP (T-Ap-HTB) in vitro. Zn-Ap-HTB and Mg-Ap-HTB mixed with liquid-nitrogen-treated tumor tissue markedly inhibited the in vivo development of rechallenged Lewis lung carcinoma (LLC) cells compared with T-Ap-HTB and the unprocessed HTB mixed liquid-nitrogen-treated tumor tissue. Zn-Ap-HTB and Mg-Ap-HTB contributed to eliciting potent systemic antitumor immunity in vivo.


Nov 8, 1985·Science·L J Old
Aug 1, 1981·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·H KobatakeH Kushida
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·C BeadlingK A Smith
Jan 1, 1993·Vaccine·R K GuptaC K Gupta
Dec 5, 1997·Immunology Today·N WellinghausenL Rink
Feb 19, 2000·Journal of Biomedical Materials Research·A ItoT Tateishi
Feb 22, 2002·Journal of Biomedical Materials Research·Atsuo ItoSadao Tsutsumi
Jun 19, 2003·American Journal of Physiology. Endocrinology and Metabolism·Bin BaoMichele Godmere
Sep 2, 2003·Cytokine & Growth Factor Reviews·Wendy T WatfordJohn J O'Shea
Jul 13, 2004·Journal of UOEH·Tsutomu SugiuraUki Yamashita
Jul 13, 2004·Science·Joseph N Blattman, Philip D Greenberg
Apr 7, 2005·Nature Medicine·Achal PashineJeffrey B Ulmer
Aug 8, 2006·Nature Immunology·Hidemitsu KitamuraToshio Hirano
Nov 2, 2007·Vaccine·Neil L Berinstein
Nov 6, 2007·Advances in Immunology·Jamie R Schoenborn, Christopher B Wilson
Jul 23, 2008·Acta Biomaterialia·Xia LiR Z LeGeros
Jan 13, 2009·Nature Materials·Omar A AliDavid J Mooney
Aug 28, 2009·Current Opinion in Clinical Nutrition and Metabolic Care·Ananda S Prasad
Sep 5, 2009·Acta Biomaterialia·Xiupeng WangAyako Oyane
Nov 20, 2010·Journal of Translational Medicine·Erica JohnMichael T Lotze
May 8, 2013·Journal of Biomedical Materials Research. Part a·Xiupeng WangTadao Ohno

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dynamic light scattering
x-ray spectroscopy
infrared spectrometry

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