Zn2+ ions: modulators of excitatory and inhibitory synaptic activity

The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry
Trevor G SmartPaul S Miller

Abstract

The role of Zn(2+) in the CNS has remained enigmatic for several decades. This divalent cation is accumulated by specific neurons into synaptic vesicles and can be released by stimulation in a Ca(2+)-dependent manner. Using Zn(2+) fluorophores, radiolabeled Zn(2+), and selective chelators, the location of this ion and its release pattern have been established across the brain. Given the distribution and possible release under physiological conditions, Zn(2+) has the potential to act as a modulator of both excitatory and inhibitory neurotransmission. Excitatory N-methyl-D-aspartate (NMDA) receptors are directly inhibited by Zn(2+), whereas non-NMDA receptors appear relatively unaffected. In contrast, inhibitory transmission mediated via GABA(A)receptors can be potentiated via a presynaptic mechanism, influencing transmitter release; however, although some tonic GABAergic inhibition may be suppressed by Zn(2+), most synaptic GABA receptors are unlikely to be modulated directly by this cation. In the spinal cord, glycinergic transmission may also be affected by Zn(2+) causing potentiation. Recently, the penetration of synaptically released Zn(2+) into neurons suggests that this ion has the potential to act as a direct transmitter,...Continue Reading

References

Nov 1, 1992·Journal of Chemical Neuroanatomy·C J FredericksonG A Howell
Aug 1, 1991·British Journal of Pharmacology·T G SmartR L Huganir
Jul 1, 1991·The Journal of Membrane Biology·T J Simons
Apr 1, 1990·British Journal of Pharmacology·T G Smart, A Constanti
Sep 1, 1989·The Journal of Physiology·Y Ben-AriJ L Gaiarsa
Dec 8, 1989·The Journal of Comparative Neurology·J Pérez-ClausellG Danscher
Jan 1, 1989·International Review of Neurobiology·C J Frederickson
Nov 1, 1988·Hearing Research·C J FredericksonG Danscher
Mar 1, 1988·Journal of Neurochemistry·J WensinkC J Van den Hamer
Jun 1, 1972·Journal of Neurochemistry·I L Crawford, J D Connor
Jun 22, 1982·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·T G Smart, A Constanti
Sep 30, 1983·Neuroscience Letters·T G Smart, A Constanti
Apr 19, 1984·Nature·S Y Assaf, S H Chung
Apr 19, 1984·Nature·G A HowellC J Frederickson
Feb 1, 1994·Progress in Neurobiology·T G SmartB J Krishek
Jan 1, 1993·Neuron·J H WeissD W Choi
Aug 1, 1994·Neuropharmacology·N L Harrison, S J Gibbons
Jul 1, 1994·Pflügers Archiv : European journal of physiology·X Xie, T G Smart
Sep 1, 1993·Journal of Neurophysiology·F M Zhou, J J Hablitz
Aug 1, 1996·Journal of Chemical Neuroanatomy·J Pérez-Clausell

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Citations

Aug 25, 2012·Cell and Tissue Research·Joanna WojtkiewiczSławomir Gonkowski
Jun 11, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Toshiyuki FukadaToshio Hirano
Jan 12, 2012·Bulletin of Experimental Biology and Medicine·A F Yakimovskii, I I Stepanov
Apr 27, 2007·Cellular and Molecular Neurobiology·Punita BhallaD K Dhawan
Jul 17, 2012·Chemical Reviews·Kasper P Kepp
Dec 3, 2005·The Cerebellum·Mark J Wall
Dec 3, 2010·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Raúl BallestínXavier Ponsoda
Mar 10, 2010·Cerebral Cortex·Noritaka IchinoheKathleen S Rockland
Jul 13, 2007·Biological Reviews of the Cambridge Philosophical Society·Manuel Zarzo
May 16, 2008·Science Signaling·Alan R Kay, Katalin Tóth
Jan 31, 2012·Journal of Toxicology·Sanah SadiqDietrich Büsselberg
Sep 9, 2011·PloS One·Gonzalo E Yévenes, Hanns Ulrich Zeilhofer
Dec 25, 2013·PloS One·Ole GrønliRolf Wynn
Sep 9, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ehud ChorinMichal Hershfinkel
Mar 6, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Limor BesserMichal Hershfinkel
Jun 24, 2014·Biochemistry. Biokhimii︠a︡·E V StelmashookS N Illarioshkin
Jun 2, 2012·Future Medicinal Chemistry·Lin W Hung, Kevin J Barnham
Jan 25, 2014·Molecular Brain·Jun Liu, Yu Tian Wang
Jun 10, 2014·Neurochemistry International·Raúl BallestínEmilio Varea
Apr 22, 2014·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Kamil JurowskiWojciech Piekoszewski
Jun 30, 2014·Pesticide Biochemistry and Physiology·Anshoo Malhotra, D K Dhawan
Sep 17, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Carla Marchetti
Jul 5, 2011·Nature Neuroscience·Chihiro NozakiBrigitte L Kieffer
Nov 19, 2011·Expert Review of Neurotherapeutics·Alexandra I MotMarcus W Brazier
May 21, 2005·The Journal of Physiology·Paul S MillerTrevor G Smart
Mar 31, 2007·The Journal of Physiology·Stephen H Hadley, Jahanshah Amin
Dec 1, 2007·The Journal of Physiology·Kevin Erreger, Stephen F Traynelis
Dec 27, 2011·Pharmacology & Therapeutics·Haythum O TayebFrank I Tarazi
Dec 24, 2011·Biochemical Pharmacology·Mark W FleckLindsay B Hough
Feb 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Bernadeta SzewczykGabriel Nowak
Jan 26, 2010·Trends in Pharmacological Sciences·Paul S Miller, Trevor G Smart
Oct 24, 2009·Neuroscience·Y Yukutake, M Yasui
Nov 26, 2008·Brain Research Reviews·Amy S Nakashima, Richard H Dyck
Dec 10, 2015·Scientific Reports·Michael S HildebrandChristopher A Reid
Mar 21, 2008·Neuroscience·P PaolettiM Casado

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