Zn(2+)-selective switch of duplex to hairpin DNA

Inorganic Chemistry
Stephanie A SanderJanet R Morrow

Abstract

DNA sequences that undergo large changes in secondary structure upon binding of small molecules are the basis for molecular switches. Here we report a Zn(2+) complex that promotes the conversion of a fully complementary DNA double helix into DNA hairpins. The conformational switch is promoted by an isolated Zn(2+) complex or by free ZnCl2 and a macrocyclic ligand. The switch is selective for Zn(2+) over biologically relevant transition-metal ions including Cu(2+) and Fe(2+). The dual ligand/DNA switch is an approach that may improve the selectivity for metal-ion-sensing applications.

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Citations

Jul 9, 2017·Chemistry : a European Journal·Zhen Yu, James A Cowan
Jul 30, 2015·Chemistry : a European Journal·Tuomas LönnbergSteven Rokita
Feb 22, 2018·Nanoscale·Scott G HarrounAlexis Vallée-Bélisle

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