ZNF281 Promotes Growth and Invasion of Pancreatic Cancer Cells by Activating Wnt/β-Catenin Signaling

Digestive Diseases and Sciences
Yu QianSuhua Xia

Abstract

Zinc finger protein 281 (ZNF281) has been identified to be involved in embryonic stem cell differentiation and tissue development. Also, ZNF281 was found in various types of cancers. However, its biological functions and clinical significance in pancreatic cancer remain elusive. To explore the role of ZNF281 in pancreatic cancer cells proliferation and invasion. ZNF281 expression was examined in public database Oncomine and cBioPortal. The correlation between ZNF281 and clinicopathological features was measured, and Kaplan-Meier method was used to measure the overall survival and recurrence-free survival in the TCGA cohort. Ectopic expression and knockdown of ZNF281 were performed to measure the impact on cell proliferation and invasion. Western blot and immunoprecipitation were further used to identify the ZNF281 interacting proteins. Topflash luciferase assay was used to detect the Wnt/β-catenin signaling activation. ZNF281 was predominantly up-regulated in pancreatic cancer tissues and significantly associated with advanced stage. Meanwhile, the high expression of ZNF281 indicated shorter overall survival and recurrence-free survival and ZNF281 could be an independent prognostic factor of pancreatic cancer. ZNF281 promoted c...Continue Reading

References

Mar 26, 2003·The American Journal of Pathology·Christine A Iacobuzio-DonahueMichael Goggins
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Robert GrützmannHans Detlev Saeger
May 4, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Davendra SegaraSusan M Henshall
Nov 10, 2006·Nature·Jianlong WangStuart H Orkin
Jan 17, 2009·Cancer Research·Christopher D ScharerCarlos S Moreno
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Oct 29, 2010·Nature·Shinichi YachidaChristine A Iacobuzio-Donahue
Apr 4, 2013·Science Signaling·Jianjiong GaoNikolaus Schultz
Feb 3, 2015·Nature Communications·Jianfei XueSuyun Huang
Oct 30, 2015·Nature Communications·Boshi WangYongzhong Liu
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 30, 2016·Journal of Experimental & Clinical Cancer Research : CR·Tingting LiWenting Liao
Feb 24, 2016·Proceedings of the National Academy of Sciences of the United States of America·Xinhong LimRoeland Nusse
Jun 28, 2016·Cell Stem Cell·Miguel FidalgoJianlong Wang
Nov 28, 2016·Neoplasia : an International Journal for Oncology Research·Makoto SanoBrian C Lewis
Jan 27, 2017·American Journal of Physiology. Cell Physiology·Chuanpit NinsontiaPithi Chanvorachote

❮ Previous
Next ❯

Citations

Sep 5, 2019·International Journal of Molecular Sciences·Monish Ram MakenaKartick C Pramanik
Jun 3, 2021·Cancers·Anna StarzyńskaBarbara Alicja Jereczek-Fossa
Aug 25, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y Taank, N Agnihotri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.