ZNF423 and ZNF521: EBF1 Antagonists of Potential Relevance in B-Lymphoid Malignancies

BioMed Research International
Maria MesuracaGiovanni Morrone

Abstract

The development of the B-lymphoid cell lineage is tightly controlled by the concerted action of a network of transcriptional and epigenetic regulators. EBF1, a central component of this network, is essential for B-lymphoid specification and commitment as well as for the maintenance of the B-cell identity. Genetic alterations causing loss of function of these B-lymphopoiesis regulators have been implicated in the pathogenesis of B-lymphoid malignancies, with particular regard to B-cell acute lymphoblastic leukaemias (B-ALLs), where their presence is frequently detected. The activity of the B-cell regulatory network may also be disrupted by the aberrant expression of inhibitory molecules. In particular, two multi-zinc finger transcription cofactors named ZNF423 and ZNF521 have been characterised as potent inhibitors of EBF1 and are emerging as potentially relevant contributors to the development of B-cell leukaemias. Here we will briefly review the current knowledge of these factors and discuss the importance of their functional cross talk with EBF1 in the development of B-cell malignancies.

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Citations

Oct 21, 2016·Genesis : the Journal of Genetics and Development·Ming YuKathryn E Hentges
Oct 3, 2017·PLoS Pathogens·Laura V GlaserBettina Kempkes
Dec 21, 2018·International Journal of Molecular Sciences·Emanuela ChiarellaGiovanni Morrone
Jun 6, 2018·Frontiers in Endocrinology·Heather M BondGiovanni Morrone
Jun 20, 2020·PLoS Pathogens·Craig D TiptonCaleb D Phillips
Aug 22, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Maria MesuracaGiovanni Morrone
Aug 28, 2021·International Journal of Molecular Sciences·Emanuela ChiarellaMaria Mesuraca

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Methods Mentioned

BETA
gene knockout
CHIP-seq
transgenic

Software Mentioned

geNetClassifier
R

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