Zoledronic Acid in Osteoporotic Vertebral Compression Fractures Treated With Percutaneous Kyphoplasty: A Meta-Analysis.

Frontiers in Surgery
Peng TianXin-Long Ma

Abstract

Background: We performed a meta-analysis to evaluate the efficacy and safety of zoledronic acid combined with percutaneous kyphoplasty (PKP) in treating osteoporotic vertebral compression fractures (OVCFs). Methods: Eligible scientific articles published prior to July 2020 were retrieved from the PubMed, Springer, ScienceDirect, and Cochrane Library databases. The statistical analysis was performed with RevMan 5.1. Results: Three randomized controlled trials (RCTs) and 2 non-RCTs met the inclusion criteria. The present meta-analysis revealed that zoledronic acid combined with PKP is associated with a higher BMD, a better quality of life, less severe low back pain, and fewer additional vertebral body fractures than is percutaneous vertebral augmentation alone. Conclusions: Compared with PKP only, zoledronic acid combined with percutaneous vertebral augmentation is beneficial for OVCFs.

References

Apr 27, 2004·Journal of Bone and Mineral Metabolism·Annie W C Kung
Feb 3, 2005·Journal of Spinal Disorders & Techniques·Marta L VillarragaAvram A Edidin
Jan 25, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R G G RussellM J Rogers
Dec 25, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S VasikaranUNKNOWN IOF-IFCC Bone Marker Standards Working Group
Dec 14, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Young-Joon RhoYoung Il Chun
Jan 30, 2014·Journal of Endocrinological Investigation·R SpiegelC Kasperk
Apr 23, 2014·Nature Reviews. Endocrinology·Jane A CauleyGhada El-Hajj Fuleihan
Jun 7, 2014·Journal of Orthopaedic Surgery and Research·Deting XueZhijun Pan
Feb 9, 2016·Current Medical Research and Opinion·Tung-Yi LinWen-Jer Chen
Oct 16, 2016·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J T SchousboeK E Ensrud
Mar 23, 2017·Journal of Bone Metabolism·Ji-Hye ByunYong-Chan Ha
Aug 23, 2017·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Bin LiuHaiyang Yu
Apr 13, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J ZhangD Zhao

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