Zoledronic acid inhibits visceral metastases in the 4T1/luc mouse breast cancer model

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
T HiragaT Yoneda

Abstract

It is established that bisphosphonates (BPs), specific inhibitors of osteoclasts, have beneficial effects on bone metastases of breast cancer. In addition, recent studies have reported that BPs have anticancer effects and suppress visceral metastases, too. However, the results of clinical studies are still conflicting. In the present study, we examined the effects of the BP zoledronic acid (ZOL), one of the most potent BPs currently available, on visceral metastases of breast cancer using an animal model in which mouse breast cancer cells 4T1/luc implanted at the orthotopic mammary fat pad spontaneously metastasize to multiple organs including bone, lung, and liver in female BALB/c mice. The 4T1/luc-bearing mice received single or four i.v. injections of ZOL (0.5 or 5 microg/mouse) during the whole experimental period. Bone metastases were reduced by the ZOL treatment. More importantly, ZOL significantly suppressed lung and liver metastases. Furthermore, ZOL prolonged overall survival of the tumor-bearing mice. Of interest, apoptosis in 4T1/luc cells colonized in bone was increased by ZOL; however, those in lung were not changed. In vitro studies demonstrated that ZOL inhibited cell migration and invasion and promoted apoptosis...Continue Reading

References

Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J Pfeilschifter, G R Mundy
Aug 6, 1998·The New England Journal of Medicine·I J DielG Bastert
Mar 10, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·R L TheriaultD J Reitsma
May 13, 1999·Bone·M J RogersR G Russell
Sep 1, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J J BodyJ Ford
Nov 24, 1999·The Journal of Biological Chemistry·L LiuJ M Harlan
Mar 15, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B E HillnerD G Pfister
Nov 25, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·O FromigueJ J Body
Jan 3, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T SaartoI Elomaa
May 18, 2001·Nature·L A Liotta, E C Kohn
May 25, 2002·Seminars in Cancer Biology·Isaiah J Fidler
Aug 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Trevor PowlesLiisa Pylkkänen
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Aug 17, 2002·The Journal of Pharmacology and Experimental Therapeutics·Jeanette WoodJonathan R Green
Oct 2, 2002·Breast Cancer Research and Treatment·Toshimi MichigamiToshiyuki Yoneda
Aug 15, 2003·International Journal of Cancer. Journal International Du Cancer·Toru HiragaToshiyuki Yoneda

❮ Previous
Next ❯

Citations

May 7, 2008·Cancer Immunology, Immunotherapy : CII·Daniele SantiniFabrizio Poccia
Mar 1, 2008·International Journal of Clinical Oncology·Norio Kohno
Apr 26, 2008·Apoptosis : an International Journal on Programmed Cell Death·Lilian SewingRüdiger Göke
Oct 1, 2011·Breast Cancer Research and Treatment·Penelope D OttewellIngunn Holen
Dec 13, 2006·Cancer Metastasis Reviews·Muzaffer Cicek, Merry Jo Oursler
May 23, 2006·Clinical & Experimental Metastasis·S H Tannehill-GreggT J Rosol
Oct 8, 2013·Clinical & Experimental Metastasis·Xujuan YangWilliam G Helferich
Jan 5, 2013·Clinical & Experimental Metastasis·Naohisa FutamuraYoshihiro Nishida
Jul 19, 2005·Journal of Mammary Gland Biology and Neoplasia·Wende Kozlow, Theresa A Guise
Apr 29, 2010·Current Osteoporosis Reports·Larry J Suva
Oct 2, 2013·Nature Reviews. Clinical Oncology·Naomi Gronich, Gad Rennert
May 29, 2009·The New England Journal of Medicine·Frederik Wenz
Feb 14, 2009·The New England Journal of Medicine·Michael GnantC Marth
May 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M GalloN Normanno
Jun 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P HadjiJ Green
Feb 22, 2007·Journal of the National Cancer Institute·Florence DaubinéPhilippe Clézardin
Aug 13, 2008·Journal of the National Cancer Institute·Penelope D OttewellIngunn Holen
Dec 18, 2004·Current Opinion in Rheumatology·Jorge Casas-Ganem, John H Healey
Feb 11, 2010·Anti-cancer Drugs·Venkateswaran SubramaniamSerge Jothy
Feb 22, 2008·Journal of Veterinary Internal Medicine·J M WypijS C Charney
Oct 19, 2011·Journal of Translational Medicine·Thea L Rogers, Ingunn Holen
Dec 24, 2010·Breast Cancer Research : BCR·Ingunn Holen, Robert E Coleman
Sep 28, 2012·Breast Cancer Research : BCR·Richard A SteinmanSteffi Oesterreich
Oct 2, 2009·Magyar onkologia·Lilla Tamási
Jan 1, 2009·OncoTargets and Therapy·Michael Gnant
Dec 22, 2009·Future Oncology·April A N Rose, Peter M Siegel
Nov 17, 2012·World Journal of Gastroenterology : WJG·Yun Hwan OhSang Min Park
Jun 23, 2011·Biogerontology·Ligia J DominguezMario Barbagallo
Mar 23, 2011·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Joaquim Bosch-BarreraCatherine Van Poznak
Apr 13, 2011·Journal of Cell Communication and Signaling·Osama Hussein, Svetlana V Komarova
Nov 3, 2006·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Farzan SiddiquiRobert L Ullrich
Oct 6, 2015·International Journal of Cancer. Journal International Du Cancer·Junko KatoKazuhiro Yoshida
Feb 24, 2011·Expert Review of Anticancer Therapy·Gennaro DanieleFrancesco Perrone
May 14, 2011·Expert Opinion on Drug Metabolism & Toxicology·Antonella De LucaNicola Normanno
Mar 10, 2011·Expert Opinion on Pharmacotherapy·Giuseppe ToniniDaniele Santini

❮ Previous
Next ❯

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