Zoledronic acid protects against osteosarcoma-induced bone destruction but lacks efficacy against pulmonary metastases in a syngeneic rat model

International Journal of Cancer. Journal International Du Cancer
Agatha LabrinidisAndreas Evdokiou

Abstract

Osteosarcoma (OS) is the most common primary malignant tumor of bone in children and adolescents. In spite of successful control of the primary tumor, death from lung metastasis occurs in more than a third of patients. To investigate the efficacy of zoledronic acid (ZOL) on the development, progression and metastatic spread of OS, we used a rat model of OS, with features of the disease similar to human patients, including spontaneous metastasis to lungs. Rat OS cells were inoculated into the tibial marrow cavity of syngeneic rats. OS development was associated with osteolysis mixed with new bone formation, adjacent to the periosteum and extended into the surrounding soft tissue. Metastatic foci in the lungs formed 3-4 weeks postcancer cell transplantation. Treatment with a clinically relevant dose of ZOL was initiated 1 week after tumors were established and continued once weekly or as a single dose. ZOL preserved the integrity of both trabecular and cortical bone and reduced tumor-induced bone formation. However, the overall tumor burden at the primary site was not reduced because of the persistent growth of cancer cells in the extramedullary space, which was not affected by ZOL treatment. ZOL treatment failed to prevent the m...Continue Reading

References

Jan 1, 1996·Annual Review of Biochemistry·F L Zhang, P J Casey
Feb 1, 1997·Acta Orthopaedica Scandinavica. Supplementum·G SaeterO P Solheim
Dec 9, 1997·Journal of the National Cancer Institute·H S ChanV Ling
Feb 24, 2001·Critical Reviews in Eukaryotic Gene Expression·J M Chirgwin, T A Guise
Jul 17, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S M AliA Lipton
Mar 7, 2002·Breast Cancer Research : BCR·Siddhika G Senaratne, Kay W Colston
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Aug 18, 2004·In Vitro Cellular & Developmental Biology. Animal·Erica Suchman, Jonathan Carlson
Oct 2, 2004·The Oncologist·Jonathan R Green
Nov 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dieter KabelitzMargot Zöller
Mar 10, 2005·International Journal of Cancer. Journal International Du Cancer·Kiyoshi SatoTaira Maekawa
Apr 8, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·B KubistaW Berger
Jul 25, 2006·Cancer Treatment Reviews·Alessandra LonghiGaetano Bacci
Sep 8, 2006·Wiener klinische Wochenschrift·Arno WutzlArnulf Baumann
Nov 23, 2006·Cancer Letters·Maria Serena BenassiPiero Picci
Jan 25, 2007·Orphanet Journal of Rare Diseases·Piero Picci
Feb 22, 2007·Journal of the National Cancer Institute·Florence DaubinéPhilippe Clézardin
Jun 5, 2007·Current Opinion in Oncology·Stefano Ferrari, Emanuela Palmerini
Nov 9, 2007·The Breast : Official Journal of the European Society of Mastology·R Coleman
Dec 20, 2007·Molecular Cancer Therapeutics·Crispin R Dass, Peter F M Choong
Apr 22, 2008·Cancer Treatment Reviews·M C WinterR E Coleman
Sep 10, 2008·Current Oncology Reports·Chand Khanna
Apr 30, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Agatha LabrinidisAndreas Evdokiou

❮ Previous
Next ❯

Citations

Mar 5, 2011·Clinical & Experimental Metastasis·Tobie D WolfeThomas J Rosol
Oct 22, 2011·Cell Stress & Chaperones·Mariarita RomanucciLeonardo Della Salda
Jul 9, 2013·Trends in Molecular Medicine·Marco DuranteKathryn D Held
Dec 12, 2012·Sarcoma·Nathalie GasparLaurence Brugieres
Apr 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Emily E AndersonKaren J Reynolds
Aug 1, 2012·Biochimica Et Biophysica Acta·Liliana Endo-MunozNicholas A Saunders
Dec 3, 2014·Micron : the International Research and Review Journal for Microscopy·Mambaye N'DiayeDaniel Chappard
May 15, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Robert E GoldsbyNeyssa Marina
Jun 3, 2016·Journal of Veterinary Internal Medicine·M L ByrumT M Fan
Jun 22, 2016·The Lancet Oncology·Sophie Piperno-NeumannUNKNOWN French Sarcoma Group (GSF-GETO)

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Daniela MerlottiRanuccio Nuti
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Séverine BattagliaFrançoise Redini
Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Agatha LabrinidisAndreas Evdokiou
© 2022 Meta ULC. All rights reserved