Oct 11, 1975

Zollinger-Ellison syndrome treated medically by an inhibitor of H2 histamine receptors

La Nouvelle presse médicale
S BonfilsJ Marteau


Metiamide an histamine H2-receptors antagonist has been used to treat a case of Zollinger-Ellison syndrome characterized by a long standing diarrhea, an important gastric hypersecretion and a moderatly elevated plasma gastrin but without digestive ulceration. At the dose of 600 mg per day, Metiamide induced a complete suppression of acid secretion, an effect which lasted for 15 days after stopping the drug. Accordingly and since the only finding at time of laparotomy was a small lymph node enlarged with endocrine metastatic tissue, the stomach was left intact and Metiamide pursued. During the first 4 months of chronic administration of Metiamide, acid secretion was maintained at levels below 25 p.cent of initial values. Ulteriorly however, although dosages of Metiamide were increased, acid hypersecretion resumed and a duodenal ulcer developed. Total gastrectomy was then performed 11 months after the beginning of Metiamide. In spite of the failure of Metiamide treatment, the long term follow up of this case of Zollinger-Ellison Syndrome, allowed us to get theoretical and practical informations.

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Mentioned in this Paper

Histamine Measurement
Gastric Juice
Controlled-Release Preparations
Metiamide Monohydrochloride
Antagonist Muscle Action
Structure of Pyloric Gland
Histamine Receptor
Secretory Rate
Receptors, Drug

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