PMID: 6324497Feb 17, 1984Paper

Zollinger-Ellison syndrome

Wiener klinische Wochenschrift
H D Becker

Abstract

The Zollinger-Ellison syndrome (ZES) is caused by mainly pancreatic, gastrin-producing tumours, which show a high rate of malignancy. The clinical picture is dominated by gastric hypersecretion, which results in the development of peptic ulcerations of the stomach and duodenum, reflux esophagitis, or diarrhea. The differentiation from other types of hypergastrinemia is done by provocative tests, mainly the secretin-test. Because of the high malignancy rate, therapeutically, a symptomatic treatment of gastric hypersecretion by H2-receptor antagonists or in cases of ineffective conservative treatment total gastrectomy is performed. In patients with duodenal gastrinomas or in the rare cases with benign pancreatic tumours resection of the tumours is the therapy of choice.

References

May 1, 1979·Radiology·S R MillsD M McCarthy
Dec 1, 1977·Annals of Internal Medicine·C W DeveneyL W Way
Oct 1, 1983·Annals of Surgery·C W DeveneyL W Way
Apr 1, 1980·Radiology·N R DunnickD M McCarthy
Jun 24, 1982·The New England Journal of Medicine·M M WolfeJ E McGuigan
Jan 1, 1983·Annals of Internal Medicine·R T JensenM J Collen
Jan 1, 1984·American Journal of Surgery·B E StabileE Passaro

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Citations

Aug 1, 1986·World Journal of Surgery·M MignonS Bonfils
Oct 1, 1987·World Journal of Surgery·H J KlotterM Rothmund
Oct 3, 2006·Journal of Hepato-biliary-pancreatic Surgery·Hui ZhouHans-Peter Fischer
Jan 1, 1991·World Journal of Surgery·J A Norton, R T Jensen

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