Zolpidem dependency and withdrawal seizure: a case report study

Iranian Red Crescent Medical Journal
Seyed Alireza Haji Seyed JavadiMarjan Nassiri-Asl

Abstract

Zolpidem is a short acting inducer of sleep and thought to lack benzodiazepine properties such as anxiolysis, anticonvulsion, muscle relaxation and side effects such as dependency. Recently, some cases of Zolpidem abuse and dependency have been reported. In review of literature, we found that the lowest reported dosage of Zolpidem, which caused dependency, was 160 mg daily. We reported a 30-year-old unmarried Iranian woman with dysthymic disorder and chronic insomnia treated with Zolpidem irregularly. She started to use Zolpidem with 5mg per day irregularly since a year ago but augmented its daily dosage gradually to 100 to 150 mg per day in divided doses. After a period of 16 hours without taking Zolpidem she developed a withdrawal syndrome, with generalized tonic-clonic seizures for two times. She was managed with supportive care and recovered completely. Zolpidem dependency and withdrawal seizure can occur with a dosage under last reported doses. Therefore, possibility of mentioned problems cannot be excluded at any dosage and physicians should pay more attention to potential of Zolpidem to create these adverse effects.

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Citations

Sep 14, 2015·Current Psychiatry Reports·Vincent F CapaldiCarla M York
Aug 1, 2016·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Josef Finsterer, Marlies Frank
Jun 11, 2019·Expert Opinion on Drug Safety·Fabio LugoboniGiovanni Addolorato
Apr 24, 2021·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Laura OrsoliniUmberto Volpe
Aug 28, 2021·Revista colombiana de psiquiatría·Gonzalo Emmanuel Barbosa Eyler, Jhoan Vidal Utria Castro
Apr 8, 2020·Psychotherapy and Psychosomatics·Fiammetta Cosci, Guy Chouinard

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Methods Mentioned

BETA
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