Zolpidem does not serve as reinforcer in humans subjected to simulated shift work.

Drug and Alcohol Dependence
Matthew G KirkpatrickCarl L Hart

Abstract

Zolpidem attenuates shift-change-related sleep and performance disruptions. It is unknown whether these benefits alter the reinforcing effects of the drug during shift work. This study examined zolpidem-related reinforcing effects during simulated shift work. Eleven volunteers (3F, 8M) completed this 16-day within-participant, residential laboratory study. Each day participants were given an opportunity to self-administer oral zolpidem (10mg) or receive a $1 voucher immediately following a 9-h work period and immediately before going to bed. Participants worked under two shift conditions: (1) during the night shift, participants completed computerized task batteries from 00:30 to 09:30h and went to bed at 16:00h and (2) during the day shift, participants completed task batteries from 08:30 to 17:30h and went to bed at 24:00h. Shift conditions alternated three times during the study. Despite the fact that sleep, psychomotor performance, and some ratings of mood were disrupted during night-shift work, there was no significant effect of shift on choice to take zolpidem. Overall, participants selected markedly fewer zolpidem doses than monetary vouchers (17% versus 83%). Thus, zolpidem did not serve as a reinforcer even when sleep ...Continue Reading

References

Jul 1, 1992·Trends in Pharmacological Sciences·J H WoodsC P France
Jan 1, 1983·Neuropsychobiology·K Wesnes, D M Warburton
Mar 1, 1995·Psychological Medicine·I NiedhammerM J Marne
Mar 1, 1994·Psychopharmacology·K SilvermanR R Griffiths
May 27, 1999·Annals of Medicine·C I Eastman, S K Martin
Aug 25, 2000·Pharmacopsychiatry·M SoykaH J Möller
Dec 19, 2000·Occupational and Environmental Medicine·K Reid, D Dawson
Jun 13, 2001·Psychopharmacology·M HaneyM W Fischman
Aug 21, 2001·Psychopharmacology·C L HartM W Fischman
Nov 7, 2001·Journal of Sleep Research·K M SharkeyC I Eastman
Nov 6, 2003·Experimental and Clinical Psychopharmacology·Carl L HartRichard W Foltin
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Carl L HartRichard W Foltin
Dec 22, 2005·Experimental and Clinical Psychopharmacology·Todd C HelmusChris-Ellyn Johanson
Oct 4, 2008·European Journal of Pharmacology·Stephanie C LicataScott E Lukas
Jun 16, 2009·Aviation, Space, and Environmental Medicine·Roscoe O Van Camp

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.