PMID: 15352681Sep 9, 2004Paper

Zolpidem for postanoxic spasticity

Southern Medical Journal
Farhad F ShadanLawrence E Kline

Abstract

A 28-year-old male sustained anoxic brain damage following aborted cardiac arrest, and subsequently developed severe muscular rigidity and spasticity involving all extremities. The spasticity was refractory to the standard regimens used for spastic hypertonia. Zolpidem dramatically inhibited muscular rigidity, spasticity, and dystonic posturing in a dose-dependent manner, resulting in a sustained improvement of his global performance over four years. The authors postulate a central mechanism of action by selective inhibition of GABAergic inhibitory neurons, and suggest a controlled clinical study to investigate the potential efficacy of zolpidem in relieving spasticity related to postanoxic brain injury.

References

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Aug 14, 1999·The New England Journal of Medicine·A DanieleA R Bentivoglio

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Citations

Jun 16, 2012·The Consultant Pharmacist : the Journal of the American Society of Consultant Pharmacists·Jeannette Y Wick
Nov 6, 2014·Case Reports in Medicine·Andrew Young Chang, Erica Weirich
Jun 10, 2015·Sleep Medicine Clinics·Philip M Becker, Manya Somiah
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Julia DammRainer Rupprecht
Jan 5, 2008·American Journal of Physical Medicine & Rehabilitation·Sara I Cohen, Thao T Duong

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