PMID: 2111156Mar 1, 1990Paper

Zolpidem intoxication mimicking narcotic overdose: response to flumazenil

Human & Experimental Toxicology
P LheureuxR Askenasi

Abstract

Zolpidem is a recently introduced sleep-inducer which is thought to act on the central-type benzodiazepine receptors. This observation is the first report of drug poisoning with this compound. The toxic response was characterized by the development of a profound but short-lasting coma, associated with pin-point pupils and respiratory depression, as observed in a narcotic overdose. These clinical signs were not influenced by the administration of naloxone, but responded dramatically to flumazenil. Some analytical data on zolpidem toxicokinetics are presented.

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Citations

Sep 1, 1995·Psychopharmacology·N J WesenstenG L Belenky
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Jun 25, 2004·Journal of Toxicology. Clinical Toxicology·Donna L Seger
Feb 16, 2021·Journal of Clinical Psychopharmacology·Domenico De DonatisLaura Mercolini

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