PMID: 16642886Apr 29, 2006Paper

Zolpidem reduces postoperative pain, fatigue, and narcotic consumption following knee arthroscopy: a prospective randomized placebo-controlled double-blinded study

The Journal of Knee Surgery
Robert Z TashjianPaul D Fadale

Abstract

Sixty-eight patients undergoing outpatient knee arthroscopy for treatment of meniscal tears or loose bodies were divided into three treatment groups (zolpidem [24 patients], control [24 patients], and placebo [20 patients]). All groups received postoperative hydrocodone and ibuprofen. Patients in the zolpidem group received a single dose of zolpidem tartrate for the first seven postoperative nights. Patients in the placebo group received a gelatin capsule similar in appearance to zolpidem and patients in the control group received only hydrocodone and ibuprofen. Patients in the control group demonstrated significantly worse mean daily postoperative pain and more daily postoperative fatigue on visual analog scales when compared with the zolpidem group (P=.03 and P=.04, respectively). Patients in the placebo group had worse daily postoperative pain and more daily postoperative fatigue when compared to the zolpidem group, although these differences did not reach statistical significance (P=.15, power=0.6; and P=.27, power=0.48, respectively). Patients in the control group consumed significantly higher quantities of hydrocodone/acetaminophen postoperatively (P=.04) than patients in the zolpidem group. Finally, patients in the place...Continue Reading

Citations

Feb 20, 2009·Orthopedics·Michell Ruiz-Suarez, F Alan Barber
Apr 13, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Matthew RobertsGeoffrey Mitchell
Nov 10, 2017·Current Opinion in Anaesthesiology·Xian Su, Dong-Xin Wang
Feb 15, 2019·Pain Practice : the Official Journal of World Institute of Pain·Martin F Bjurström, Michael R Irwin
Sep 6, 2020·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Aaron GazendamOlufemi R Ayeni
Jan 22, 2010·The Cochrane Database of Systematic Reviews·Asbjørn Hróbjartsson, Peter C Gøtzsche
Mar 19, 2009·Current Medical Research and Opinion·Michael J Brennan, Joseph A Lieberman
Jan 22, 2011·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Marc TompkinsPaul Fadale
Nov 6, 2012·Arthritis and Rheumatism·Yvonne C LeeElizabeth W Karlson
Apr 4, 2015·Yonsei Medical Journal·Chul-Hyun ChoIlseon Hwang
Sep 5, 2019·Journal of Orthopaedic Surgery and Research·Hirose ShakyaZong-Ke Zhou
Sep 20, 2020·Sleep & Breathing = Schlaf & Atmung·Bijia SongJunchao Zhu
Nov 15, 2017·The Journal of Bone and Joint Surgery. American Volume·Francis LovecchioSamuel A Taylor
Feb 6, 2010·Drugs·Timothy A Roehrs, UNKNOWN Workshop Participants

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