PMID: 2117585Jun 1, 1990Paper

Zona pellucida induces conversion of proacrosin to acrosin

International Journal of Andrology
E Töpfer-Petersen, D Cechová

Abstract

The effect of heat-solubilized zonae pellucidae (ZP) isolated from mature pig ovaries on the conversion of pig proacrosin to acrosin was examined and compared with the effects of different sulphated polysaccharides. At low concentrations, zona glycoproteins potently stimulated acrosin auto-activation. Up to 2.5 micrograms ml-1 ZP, the acceleration of acrosin activation was shown to be dependent on the ZP concentration. At higher concentrations zona glycoproteins exerted an inhibitory effect on acrosin amidase activity. A similar effect was demonstrated for fucoidan, heparin, and chondroitin sulphate. The results intimate that in vivo, the conversion of proacrosin to acrosin is regulated at the sperm-zona interface.

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Citations

Oct 24, 2009·Fertility and Sterility·Carolina VeauteMónica H Vazquez-Levin
Sep 1, 1993·Contraception·M C MahonyG D Hodgen
Sep 20, 2005·Animal Reproduction Science·Constanza J CortesRicardo D Moreno
Jun 10, 2016·Human Reproduction Update·Elisabetta Tosti, Yves Ménézo
Sep 27, 1996·The Journal of Biological Chemistry·R T Richardson, M G O'Rand
Mar 26, 2003·Reproduction in Domestic Animals = Zuchthygiene·F SinowatzG Palma
Jan 1, 1990·Andrologia·E Töpfer-PetersenA Zucker

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