Zona pellucida mediated acrosome reaction and sperm morphology

Andrologia
D R FrankenU F Habenicht

Abstract

Sperm samples from 29 men randomly selected from the andrology laboratory, were used to evaluate acrosome reaction response to solubilized human zona pellucida. Capacitated sperm samples were exposed to a solution containing 2 zona pellucidae (ZP) per microl for 60 min, after which acrosomal status were recorded using a PSA-FITC technique. Controls included samples supplied by fertile sperm donors. After completion of acrosome reaction studies, patient samples were divided according to the percentage of morphologically normal spermatozoa. Three basic groups were identified, namely, fertile donors, teratozoospermic (normal sperm morphology 5-14%; n = 25) and severely teratozoospermic (normal sperm morphology < 4%; n = 4) groups. The mean percent normal sperm were 15.8 +/- 0.9, 10.4 +/- 0.7 and 2.7 +/- 0.7, respectively, for normozoospermic donors, teratozoospermic and severely teratozoospermic men. The mean percentage (+/-SE) ZP mediated acrosome reacted sperm among teratozoospermic and severely teratozoospermic cases was 25.8% +/- 0.9 and 19.0% +/- 0.9 (P = 0.001), compared to 36.8% +/- 0.9 for the donor controls. Results were analysed and expressed as correlations between sperm morphology and acrosomal response to human solubi...Continue Reading

References

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Citations

Feb 12, 2004·Andrologia·W MiskaR Sánchez
Dec 20, 2011·Asian Journal of Andrology·Daniel R Franken, Sergio Oehninger
Mar 7, 2005·Reproductive Medicine and Biology·Ralf HenkelWolf-Bernhard Schill
Jul 24, 2013·Reproduction in Domestic Animals = Zuchthygiene·J L YánizP Santolaria
Dec 29, 2000·Andrologia·T ZeginiadouS Mantalenakis
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Vinicio BarqueroAnthony Valverde
Aug 17, 2002·Theriogenology·Jacob ThundathilReuben J Mapletoft
Oct 30, 2004·Molecular Reproduction and Development·Miyoko Kubo-IrieSumio Ishijima

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