Zonation of hepatic bile salt transporters.

Digestive Diseases and Sciences
P K BaierU Baumgartner

Abstract

Pericentral and periportal hepatocytes differ in their capacity to eliminate and velocity of eliminating bile acids and other organic anions. We wonder whether differences in the distribution of anion transporters (ntcp [M77479], besp [NM_031760], mrp2 [NM_012833], oatp1 [NM_017111], oatp2 [NM_131906]) cause the differences in bile acid excretion. Therefore, we analyzed the distribution of these anion transporters in periportal and pericentral cells by immunohistology, their mRNA by quantitative PCR, and regulating nuclear factors (NF-kappaB, HNF1, HNF3, HNF4, FXR, PXR) by gel shift assay. We did not find any differences in nuclear factors or regarding the proteins that could explain the zonal differences in anion transport.

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Citations

Aug 9, 2007·Journal of Gastroenterology and Hepatology·Stanislav MicudaJirina Martinkova
Dec 3, 2016·Biological & Pharmaceutical Bulletin·Yoshiyuki KuboKen-Ichi Hosoya
Jun 9, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Saori IkedaKen-ichi Hosoya
Mar 7, 2018·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Masanori TachikawaTetsuya Terasaki
Oct 6, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Markus G DonnerDieter Häussinger
Sep 17, 2020·American Journal of Physiology. Gastrointestinal and Liver Physiology·Norman B Javitt

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