Zonisamide add-on for drug-resistant partial epilepsy

The Cochrane Database of Systematic Reviews
Katie CarmichaelA G Marson

Abstract

The majority of people with epilepsy have a good prognosis and their seizures can be well controlled with the use of a single antiepileptic agent, but up to 30% develop refractory epilepsy, especially those with partial seizures. In this review we summarise the current evidence regarding zonisamide, when used as an add-on treatment for drug-resistant partial epilepsy. To evaluate the efficacy and tolerability of zonisamide when used as an add-on treatment for people with drug-resistant partial epilepsy. We searched the Cochrane Epilepsy Group Specialized Register (12 February 2013), the Cochrane Central Register of Controlled Trials (The Cochrane Library 2013, Issue 1) (January 2013), MEDLINE (Ovid, 1946 to 12 February 2013), SCOPUS (13 February 2013), ClinicalTrials.gov (12 February 2013) and the WHO International Clinical Trials Registry Platform ICTRP (13 February 2013). In addition, we contacted Eisai Limited (makers and licensees of zonisamide) and experts in the field to seek any ongoing/unpublished studies. Randomised, placebo-controlled, add-on trials of zonisamide in people with drug-resistant partial epilepsy. Two review authors independently selected trials for inclusion and extracted data. Outcomes were: (1) 50% or ...Continue Reading

References

Sep 1, 1988·The Japanese Journal of Psychiatry and Neurology·A ShimizuT Kawasaki
Nov 9, 1996·BMJ : British Medical Journal·A G MarsonD W Chadwick
Nov 1, 1996·Journal of Neurology, Neurosurgery, and Psychiatry·J W Sander, S D Shorvon
May 26, 1998·Epilepsy Research·A MoriL Packer
Jul 25, 2000·The Cochrane Database of Systematic Reviews·A G MarsonD W Chadwick
Nov 28, 2001·Neurology·E FaughtUNKNOWN Zonisamide 922 Trial Group
Oct 30, 2004·Seizure : the Journal of the British Epilepsy Association·Ilo E Leppik
Oct 20, 2005·The Cochrane Database of Systematic Reviews·D W Chadwick, A G Marson
Jun 8, 2007·Epilepsy Research·Michel Baulac, Ilo E Leppik

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Citations

Feb 19, 2017·Neurology·Britta WandschneiderMatthias J Koepp
Jul 28, 2020·The Cochrane Database of Systematic Reviews·Francesco BrigoNicola Luigi Bragazzi
Jun 4, 2016·Pharmacological Reviews·Martin J BrodieBernhard J Steinhoff
Oct 20, 2018·The Cochrane Database of Systematic Reviews·Francesco BrigoNicola Luigi Bragazzi
Sep 25, 2015·CNS Drugs·Anna RosatiRenzo Guerrini

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