Zonisamide therapy for refractory idiopathic epilepsy in dogs

Journal of the American Animal Hospital Association
Curtis W DeweySteven C Budsberg

Abstract

Twelve dogs with poorly controlled idiopathic epilepsy were entered into a prospective, open-label, noncomparative study. Oral zonisamide was administered as an additional therapy at a dosage adequate to achieve serum drug concentrations of 10 to 40 microg/mL. Seizure frequency before and after initiation of zonisamide therapy was recorded. A dosing interval of q 12 hours was sufficient to maintain serum zonisamide concentrations within the therapeutic range. The mean dosage of zonisamide required was 8.9 mg/kg q 12 hours. Seven (58%) dogs responded favorably, experiencing a mean reduction in seizures of 81.3%. Five dogs had an increase in seizure frequency. Mild side effects (e.g., transient sedation, ataxia, vomiting) occurred in six dogs.

References

Sep 1, 1992·Epilepsia·V E AdusumalliR D Sofia
Jan 1, 1990·Psychosomatics·C L CharlesG Tollefson
Aug 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R M WalkerG E Macallum
Jan 1, 1987·General Pharmacology·E J HammondJ R McLean
May 1, 1995·Journal of the American Animal Hospital Association·S L BergerE M Lund
Oct 1, 1994·Journal of Child Neurology·J A French, I Leppik
Sep 1, 1993·Journal of Veterinary Internal Medicine·M Podell, W R Fenner
Feb 1, 1993·Epilepsy Research·I E LeppikJ D Wallace
Aug 1, 1996·Biological & Pharmaceutical Bulletin·M ShinodaT Nabeshima
Apr 29, 1998·The Veterinary Clinics of North America. Small Animal Practice·D M Boothe
May 26, 1998·Epilepsy Research·A MoriL Packer
Feb 6, 1999·Journal of Clinical Psychopharmacology·M A FryeT A Ketter
Jun 24, 1999·Cellular and Molecular Neurobiology·T A KetterR M Post
Oct 26, 1999·Epilepsia·I E Leppik
Apr 5, 2000·Clinical Pharmacokinetics·E Perucca
Jun 1, 2000·Current Pharmaceutical Design·G GattiE Perucca
Oct 6, 2000·Biological Psychiatry·S L McElroy, P E Keck
Jun 8, 2001·Journal of Chromatography. B, Biomedical Sciences and Applications·M NakamuraY Katagiri
Nov 28, 2001·Neurology·E FaughtUNKNOWN Zonisamide 922 Trial Group
Dec 31, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Giuliana GattiEmilio Perucca
Sep 16, 2003·Chemical Research in Toxicology·Craig K Svensson

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Citations

Oct 24, 2014·BMC Veterinary Research·Marios CharalambousHolger A Volk
Jan 15, 2014·PloS One·J Jeffry HowbertGregory A Worrell
May 21, 2005·The Veterinary Journal·Susanne RieckAndrea Tipold
Apr 25, 2009·Journal of Feline Medicine and Surgery·Kerry Smith Bailey, Curtis W Dewey
Mar 4, 2014·The Veterinary Clinics of North America. Small Animal Practice·James A Lavely
Feb 24, 2016·Journal of Veterinary Internal Medicine·M PodellS R Platt
Jul 31, 2013·The Veterinary Clinics of North America. Small Animal Practice·Karen R Muñana
Nov 28, 2009·The Veterinary Clinics of North America. Small Animal Practice·William B Thomas
May 1, 2007·The Veterinary Journal·Holger A VolkKate E Chandler
Sep 21, 2006·The Veterinary Clinics of North America. Small Animal Practice·Curtis W Dewey
May 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·K OritoM Fujiwara
Nov 13, 2008·Journal of Veterinary Pharmacology and Therapeutics·D M Boothe, J Perkins
Mar 16, 2007·The Journal of Small Animal Practice·T von KlopmannA Tipold
Nov 19, 2011·Journal of Veterinary Internal Medicine·A K CookJ Barr
Oct 12, 2011·Journal of Veterinary Internal Medicine·M L MillerC W Dewey
Sep 17, 2013·The Journal of Small Animal Practice·A-M KivirantaT Jokinen
Mar 20, 2013·Epilepsia·Heidrun PotschkaWolfgang Baumgärtner
Dec 3, 2011·Journal of Veterinary Pharmacology and Therapeutics·H M WrightN M Davies
Nov 17, 2009·Journal of Veterinary Internal Medicine·K R MuñanaE E Patterson
Apr 15, 2010·Journal of Veterinary Internal Medicine·V HülsmeyerA Fischer
May 7, 2010·Journal of Veterinary Pharmacology and Therapeutics·K FukunagaK Orito
Sep 13, 2005·The Veterinary Journal·Kate Chandler
Apr 12, 2016·Journal of Veterinary Emergency and Critical Care·Jonathan A LidburyJörg M Steiner
Jul 21, 2015·Veterinary Dermatology·Amanda L AckermannElizabeth R May
Apr 19, 2015·BMC Veterinary Research·Rowena M A PackerHolger A Volk
May 30, 2012·New Zealand Veterinary Journal·J Y ChungH Y Youn
Jun 18, 2014·ILAR Journal·Edward E Patterson
Mar 29, 2008·Journal of Feline Medicine and Surgery·Daisuke HasegawaHiromitsu Orima
Apr 27, 2017·Journal of Veterinary Emergency and Critical Care·Susan Blades Golubovic, John H Rossmeisl
Jul 19, 2018·Journal of Veterinary Pharmacology and Therapeutics·Koya FukunagaKensuke Orito
Oct 6, 2007·American Journal of Veterinary Research·Chadwick L West, Katrina L Mealey
Jul 2, 2011·The Journal of Veterinary Medical Science·Malte SchwartzNatasha J Olby
Sep 2, 2011·American Journal of Veterinary Research·Michelle Brogan CarnesDawn M Boothe
Dec 3, 2016·American Journal of Veterinary Research·Jennifer R MichaelsLindsay Williams
Nov 16, 2021·Frontiers in Veterinary Science·Shinichi KanazonoAkira Hiramoto

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