Zoster vaccination is associated with a reduction of zoster in elderly patients with chronic kidney disease

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Sinéad M LanganDorothea Nitsch

Abstract

Growing epidemiological evidence demonstrates increased zoster risks in people with chronic kidney disease (CKD). Study objectives were to determine zoster vaccine effectiveness in individuals with CKD in pragmatic use. A population-based cohort study was undertaken in a 5% random sample of US Medicare from 2007 to 2009 involving 766 330 eligible individuals aged ≥65 years who were (29 785) and were not (736 545) exposed to the zoster vaccine. Incidence rates for zoster in vaccinated and unvaccinated individuals and hazard ratios for zoster comparing vaccinated with unvaccinated were determined for individuals with CKD. Time-updated Cox proportional hazards models were used, adjusting for relevant confounders. CKD was present in 183 762 (24%) of individuals (15% of vaccinees). Adjusted vaccine effectiveness [95% confidence intervals (CIs)] in individuals with CKD was 0.49 (0.36-0.65). The adjusted vaccine effectiveness in participants with both CKD and diabetes mellitus was 0.46 (95% CI 0.09-0.68). Vaccine effectiveness estimates were similar to those previously reported for the general population [vaccine effectiveness 0.48 (95% CI 0.39-0.56)]. Zoster vaccine is effective against incident zoster in older individuals with CKD. ...Continue Reading

References

Dec 19, 2002·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan L FurthUNKNOWN Southwest Pediatric Nephrology Study Group
Jan 14, 2004·Seminars in Dialysis·Annamaria Kausz, Dilip Pahari
Jun 3, 2005·The New England Journal of Medicine·M N OxmanUNKNOWN Shingles Prevention Study Group
Jul 4, 2006·Advances in Chronic Kidney Disease·Robert N Foley
Jun 23, 2011·JAMA : the Journal of the American Medical Association·Ian H de BoerJonathan Himmelfarb
Oct 15, 2011·Mayo Clinic Proceedings·Michael KlompasRafael Harpaz
Dec 20, 2011·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Chien-Chun KuoChun-Yuh Yang
May 12, 2012·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Mei-Yi WuHui-Wen Lin
Aug 10, 2013·Vaccine·Rulin C HechterHung Fu Tseng
Nov 12, 2013·The New England Journal of Medicine·Jonathan Himmelfarb, Katherine R Tuttle
May 20, 2014·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·S-Y LinC-H Kao

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Citations

May 18, 2016·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Gillian M Keating
Mar 8, 2018·Transplant Infectious Disease : an Official Journal of the Transplantation Society·Geraldine MillerKathryn Edwards
Mar 10, 2018·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Marianthi PapagianniKonstantinos Tziomalos
Mar 28, 2019·Current Medical Research and Opinion·Helen SenderovichMaheen Mujtaba
Jun 10, 2020·Expert Review of Vaccines·Thomas VerstraetenBradford D Gessner
Jun 2, 2020·International Journal of Clinical Practice·Shih-Wei LaiKuan-Fu Liao
Feb 13, 2019·Clinical Kidney Journal·John H AhnJake E Turrentine
Apr 6, 2021·Frontiers in Immunology·Marcia M L KhoNicole M van Besouw
May 21, 2021·KI Reports·Mohamad A HamadHicham I Cheikh Hassan

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