Zoster vaccine (Zostavax): a review of its use in preventing herpes zoster and postherpetic neuralgia in older adults.

Drugs & Aging
Mark Sanford, Gillian M Keating

Abstract

Individuals who have been infected with varicella zoster virus (VZV) are at risk for developing herpes zoster and this risk appears to be related to a decline in VZV-specific cell-mediated immunity (CMI). Zostavax (zoster vaccine) is a one-dose, high-potency, live, attenuated VZV vaccine that boosts VZV-specific CMI and this is its presumed mechanism of action. Zoster vaccine is registered in the EU for use in adults aged >or=50 years for the prevention of herpes zoster and herpes zoster-related postherpetic neuralgia. In the Shingles Prevention Study, a placebo-controlled trial in adults aged >or=60 years (n = 38 546), zoster vaccine led to a sustained boost of VZV-specific CMI. Over a mean herpes zoster surveillance period of 3.1 years, zoster vaccine reduced the herpes zoster-related burden of illness by 61%, reduced the incidence of herpes zoster by 51% and reduced the incidence of postherpetic neuralgia by 67%. Zoster vaccine recipients who developed herpes zoster had a shorter illness duration and severity than placebo recipients who developed herpes zoster. Zoster vaccine had continuing efficacy in a Shingles Prevention Study subpopulation followed for 7 years post-vaccination. Zoster vaccine was generally well tolerated...Continue Reading

References

Aug 1, 1992·The Journal of Infectious Diseases·M J LevinA R Hayward
Sep 1, 1994·The Journal of Infectious Diseases·M J LevinA R Hayward
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J H RexJ E Edwards
Apr 24, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K Schmader
Jun 5, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C ChidiacC de Labareyre
Dec 15, 2005·Vaccine·Fiona T ScottJudith Breuer
Jul 29, 2006·Drugs & Aging·Dean M Robinson, Caroline M Perry
Sep 7, 2006·Annals of Internal Medicine·John Hornberger, Katherine Robertus
Apr 20, 2007·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Michael B RothbergKenneth J Smith
Dec 14, 2007·Clinical and Vaccine Immunology : CVI·Larry I GildermanUNKNOWN Zostavax Protocol 010 Study Group
Jan 31, 2008·The Journal of Pain : Official Journal of the American Pain Society·John W Gnann
Feb 20, 2008·PharmacoEconomics·Tracy A LieuLisa A Prosser
Apr 19, 2008·The Journal of Infectious Diseases·M J LevinUNKNOWN Veterans Affairs Cooperative Studies Program Shingles Prevention Study Investigators
May 3, 2008·The Journal of Infectious Diseases·Kenneth SchmaderC Peter Watson
May 3, 2008·The Journal of Infectious Diseases·Michael N OxmanUNKNOWN Shingles Prevention Study Group
May 3, 2008·The Journal of Infectious Diseases·Jeffrey I Cohen
May 10, 2008·Epidemiology and Infection·A GauthierV Rémy
Aug 29, 2009·The Journal of Infectious Diseases·Adriana WeinbergUNKNOWN US Department of Veterans Affairs (VA) Cooperative Studies Program Shingles Prevention Study Investigators
Nov 17, 2009·PharmacoEconomics·Mehdi NajafzadehDavid M Patrick

❮ Previous
Next ❯

Citations

Sep 3, 2013·Current Pain and Headache Reports·Yuko Kanbayashi, Toyoshi Hosokawa
Jan 22, 2013·PharmacoEconomics·Thomas D Szucs, Alena M Pfeil
Feb 9, 2011·Immunology and Cell Biology·Daniëlle HorstEmmanuel J H J Wiertz
Jul 27, 2011·Stem Cells and Development·Xusheng WangYaojiong Wu
Jul 19, 2013·The Nurse Practitioner·Carol Calianno, Susan O'Shea
Oct 22, 2011·Clinical Nurse Specialist CNS·Patricia O'Malley
Jun 18, 2011·BMC Infectious Diseases·Bernhard UltschOle Wichmann
Apr 17, 2013·BMC Geriatrics·Renske EilersHester E de Melker
Oct 18, 2014·Expert Opinion on Drug Safety·Miguel Cordero-ComaTaygan Yilmaz
Jun 28, 2011·Expert Opinion on Emerging Drugs·Graciela Andrei, Robert Snoeck
Oct 30, 2013·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Ke MaWei Jiang
Jul 3, 2013·The Medical Clinics of North America·Kim M O'Connor, Douglas S Paauw
May 31, 2011·Autoimmunity Reviews·Micha LöbermannEmil C Reisinger
Jan 26, 2016·Journal of Medical Economics·Juan Luis Lopez-BelmonteMathieu Uhart
Apr 21, 2012·International Journal of Dermatology·Mohammad JafferanyZohra Zaidi
Oct 16, 2015·Nursing·Yvonne DʼArcy
Aug 28, 2015·International Journal of Surgery Case Reports·Darmiga ThayabaranSimon Holt
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Miriam LeviPaolo Bonanni
Dec 9, 2014·Human Vaccines & Immunotherapeutics·Donatella PanattoDaniela Amicizia
Sep 5, 2013·Current Opinion in Immunology·Ernesto Oviedo-OrtaRino Rappuoli
May 11, 2016·Clinical and Experimental Immunology·N Arnold, I Messaoudi
Dec 8, 2016·Human Vaccines & Immunotherapeutics·Giovanni GabuttiAntonio Volpi
Mar 17, 2017·BMC Infectious Diseases·Liang-Kung ChenChang Won Won
Mar 5, 2016·The Cochrane Database of Systematic Reviews·Anna M Z GagliardiBernardo G O Soares
Jun 24, 2014·The Cochrane Database of Systematic Reviews·Kristine MacartneyPeter McIntyre
Jun 15, 2014·Drugs & Aging·Pierre-Olivier Lang, Richard Aspinall
Nov 8, 2019·The Cochrane Database of Systematic Reviews·Anna Mz GagliardiEduardo Canteiro Cruz
Jan 26, 2012·Proceedings·Amanda Abramson, Alan Menter
Aug 29, 2014·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Alexander D PedenEvelyn L Forget

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.