Zosyn (piperacillin/tazobactam) reformulation: Expanded compatibility and coadministration with lactated Ringer's solutions and selected aminoglycosides.

Therapeutics and Clinical Risk Management
Narendra R DesaiHema R Dalal

Abstract

Zosyn((R)) , also known as Tazocin((R)) for injection, contains piperacillin and tazobactam and was approved by the US Food and Drug Administration in 1993 for the treatment of indicated serious infections. In 1995, United States Pharmacopoeia and European Pharmacopoeias reduced the particulate limit for injectables by 40%, based on general safety concerns. Wyeth attempted to control sporadic batch failures (associated with increased particulate formation) by shortening product expiration dating from 36 to 24 months and optimizing the stopper siliconization process. These modifications did not correct the problem completely. Wyeth reformulated Zosyn by incorporating two stabilizing functional excipients, ethylene diamine tetraacetic acid disodium salt (EDTA disodium) and sodium citrate, which solved the particulate formation problem. These two functional excipients also allowed for the first time Y-site coadministration of reformulated Zosyn product with amikacin and gentamicin at specific doses and concentrations, and with certain diluents, and the use of Ca(++) ion-containing Lactated Ringer's for admixture preparation. Reformulated Zosyn (approved 2005) may provide useful options of drug administration to healthcare professi...Continue Reading

Citations

Aug 4, 2011·The Journal of Antibiotics·Thomas G PaganoTianmin Zhu
Jan 21, 2016·Antimicrobial Agents and Chemotherapy·Anthony M NicasioPaul G Ambrose
Feb 5, 2016·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·J Nicholas O'DonnellMarc H Scheetz
Jun 21, 2013·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Elizabeth LeungMarc H Scheetz
Jun 19, 2018·Critical Care Medicine·Andrea MessoriClaudio Marinai
Aug 15, 2021·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Amanda A HolykBrian W Shippert

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR

Software Mentioned

TOPSPIN
Zosyn

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

© 2022 Meta ULC. All rights reserved