PMID: 12776869Jun 5, 2003Paper

ZP123 increases gap junctional conductance and prevents reentrant ventricular tachycardia during myocardial ischemia in open chest dogs

Journal of Cardiovascular Electrophysiology
Dezhi XingJames B Martins

Abstract

The aim of this study was to determine if the stable antiarrhythmic peptide (AAP) analogue ZP123 increases gap junctional intercellular conductance and prevents reentrant ventricular tachycardia (VT) during coronary artery occlusion. Voltage clamp experiments demonstrated that 10 nM ZP123 improved gap junctional intercellular conductance by 69% +/- 20% in pairs of guinea pig ventricular myocytes. VT was induced by programmed stimulation in alpha-chloralose anaesthetized open chest dogs 1 to 4 hours after coronary artery occlusion. Three-dimensional activation mapping was done using six bipolar electrograms on each of 23 multipolar needles in the risk zone. When VT was reproducibly induced, dogs were randomly assigned to receive either saline or ZP123 cumulatively at three dose levels (intravenous bolus followed by 30-min infusion per dose). Attempts to induce VT were repeated in each infusion period. Mass spectrometry was used to measure ZP123 plasma concentrations. Twenty-six dogs with reentrant VT were included. ZP123 significantly prevented reentrant VT at all plasma concentrations vs saline: 1.0 +/- 0.2 nM: 6/12 vs 0/12; 7.7 +/- 0.6 nM: 7/13 vs 1/12; and 69.2 +/- 5.4 nM: 9/13 vs 1/13. The preventive effect of ZP123 on reent...Continue Reading

References

Aug 15, 1989·Experientia·T ArgentieriJ R Wiggins
Nov 1, 1988·Chemical & Pharmaceutical Bulletin·Y KohamaK Yokoyama
Sep 1, 1987·Chemical & Pharmaceutical Bulletin·Y KohamaK Yokoyama
Jan 1, 1982·Journal of Pharmacobio-dynamics·S AonumaY Fujisawa
Apr 15, 1997·The Journal of Clinical Investigation·P A GuerreroJ E Saffitz
May 26, 1997·European Journal of Pharmacology·A MüllerS Dhein
Jul 1, 1997·Naunyn-Schmiedeberg's Archives of Pharmacology·A MüllerS Dhein
Feb 4, 1999·Journal of Cardiovascular Electrophysiology·X D HuangD P Zipes
Jan 15, 2000·Journal of Cardiovascular Electrophysiology·J E Saffitz
Feb 24, 2001·Pflügers Archiv : European journal of physiology·R WildersH J Jongsma
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephan WengStefan Dhein

❮ Previous
Next ❯

Citations

Nov 28, 2009·Naunyn-Schmiedeberg's Archives of Pharmacology·Stefan DheinFriedrich-Wilhelm Mohr
Sep 12, 2012·Naunyn-Schmiedeberg's Archives of Pharmacology·Joanna JozwiakStefan Dhein
Feb 12, 2013·Naunyn-Schmiedeberg's Archives of Pharmacology·Andreas SkyschallyGerd Heusch
Dec 18, 2012·Calcified Tissue International·Elina KylmäojaJuha Tuukkanen
Jun 15, 2007·The Journal of Membrane Biology·Lene Nygaard AxelsenMorten Schak Nielsen
Aug 14, 2012·The Journal of Membrane Biology·W Howard EvansLuc Leybaert
Jun 7, 2008·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Matthias HammwöhnerAndreas Goette
Apr 24, 2008·Cardiovascular Research·Xianming LinRichard D Veenstra
Jan 30, 2009·Cardiovascular Research·Anja HagenStefan Dhein
Jun 19, 2009·Cardiovascular Research·Sevasti-Maria ChaldoupiHarold V M van Rijen
Sep 24, 2010·American Journal of Therapeutics·Sony JacobNicholas Z Kerin
Sep 29, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Rakesh GopinathannairJames B Martins
Jan 19, 2013·Cardiovascular Diabetology·Kristine Boisen OlsenMorten Schak Nielsen
Apr 6, 2006·Clinical Medicine & Research·Jifen LiGlenn L Radice
Mar 15, 2006·Cell Communication & Adhesion·Ketil HauganJørgen Søberg Petersen
Dec 19, 2003·Cell Communication & Adhesion·Stefan DheinFriedrich-Wilhelm Mohr
Aug 8, 2015·Molecular Medicine Reports·Guo-Ying SuYun Zhang
Jul 8, 2010·Trends in Pharmacological Sciences·Leif CarlssonIngemar Jacobson
Feb 27, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Stanley Nattel
Sep 5, 2009·Journal of Molecular and Cellular Cardiology·John A JansenHarold V M van Rijen
Nov 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Kristina ProcidaThomas Hartig Braunstein
Nov 3, 2009·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Morten Schak Nielsen
Jun 13, 2009·Journal of Electrocardiology·Bramah Singh
Nov 6, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Vadim V FedorovIgor R Efimov
Sep 16, 2008·Biochemical Pharmacology·Ninian N LangDavid E Newby
May 1, 2007·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Dezhi XingJames B Martins
May 10, 2005·Journal of Cardiovascular Electrophysiology·Ketil HauganMorten Schak Nielsen
Jul 21, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Alexander Burashnikov, Charles Antzelevitch
Sep 12, 2007·Basic & Clinical Pharmacology & Toxicology·Anne Louise KjølbyeJørgen S Petersen
Jul 27, 2006·Basic & Clinical Pharmacology & Toxicology·Ketil HauganMasamichi Hirose
Jan 27, 2011·British Journal of Pharmacology·Elke De VuystLuc Leybaert
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Stanley Nattel
Jan 10, 2006·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Jeffrey E Saffitz
Jul 30, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Glenn I Fishman
Nov 2, 2014·Cell and Tissue Research·Pier D Lambiase, Andrew Tinker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.