PMID: 8962644Mar 1, 1996Paper

ZP3 peptide vaccine that induces antibody and reversible infertility without autoimmune oophoritis

American Journal of Reproductive Immunology : AJRI
K S TungY H Lou

Abstract

Autoantibodies to ZP3, a major glycoprotein of the zona pellucida (ZP) with sperm receptor function, can block sperm/oocyte interaction. However, only mice of certain major histocompatibility complex (MHC) haplotype respond to the ZP3 peptide. Moreover, ZP3-specific T cells can mediate ovarian autoimmune disease. A chimeric peptide has been designed that induces antibody to native ZP3 regardless of the MHC haplotype of the inbred mice tested. This results in reduction in fertility that is reversible. Infertility correlates well with ZP antibody titer, and the mice do not develop concomitant autoimmune oophoritis. The vaccine contains (1) a promiscuous foreign T-cell peptide capable of eliciting a T-cell response regardless of the animals' MHC haplotype, and (2) a modified native B-cell peptide of ZP3.

References

Jan 1, 1992·The Journal of Clinical Investigation·S H RhimK S Tung
May 1, 1988·Journal of Reproduction and Fertility·C J HendersonR J Aitken
Sep 27, 1994·Proceedings of the National Academy of Sciences of the United States of America·H NaruseK Onoé

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Citations

Mar 9, 2000·Journal of Reproductive Immunology·M R Barber, R A Fayrer-Hosken
Nov 6, 2004·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Lisa A HarrenstienJay F Kirkpatrick
Jan 20, 2016·American Journal of Reproductive Immunology : AJRI·Feng XueChen Xu
Jan 12, 2002·The American Journal of Pathology·Harini BagavantKenneth S K Tung
Nov 26, 1999·Biology of Reproduction·S M SkinnerB S Dunbar
Oct 25, 2002·Journal of Women's Health & Gender-based Medicine·Judith Luborsky

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