zur: a Zn(2+)-responsive regulatory element of Staphylococcus aureus

Microbiology
J A Lindsay, S J Foster

Abstract

A putative operon encoding a probable zinc-responsive regulatory element (zur) and components of an ABC-type transporter (mreA mreB) have been characterized in Staphylococcus aureus. The zur gene was inactivated but apparently this did not alter Zn(2+) uptake. Expression of mreAB zur is at a low level under a range of ion conditions. To allow inducible expression of the operon, a construct was made placing it under the control of the IPTG-inducible P(spac) promoter. Using this approach, it was shown that zur is able to repress expression of the entire operon in a Zn(2+)-dependent manner, and that mreA and mreB are likely to be involved in high-affinity ion uptake. zur has no apparent role in pathogenicity in a lesion model of S. aureus infection.

References

Jan 1, 1991·Methods in Enzymology·R P Novick
Feb 1, 1995·The Journal of Infectious Diseases·C DriessenL Rink
Dec 29, 1995·Gene·A M Guérout-FleuryP Stragier
Apr 16, 1998·Journal of Bacteriology·S P WatsonS J Foster
Jul 29, 1998·Molecular Microbiology·S I Patzer, K Hantke
Dec 10, 1998·Microbiology·Valerie VagnerS Dusko Ehrlich
Jun 3, 1999·Biochemistry·E W AlthausT V O'Halloran
Oct 9, 1999·Journal of Bacteriology·L EscolarV de Lorenzo

❮ Previous
Next ❯

Citations

Dec 14, 2011·Current Opinion in Microbiology·Neal D Hammer, Eric P Skaar
Jul 12, 2014·IET Nanobiotechnology·Loganathan PalanikumarChandrasekaran Balachandran
Sep 23, 2014·Environmental Microbiology·Violeta C Sein-EchaluceMaría F Fillat
Dec 18, 2007·FEMS Microbiology Letters·Nicole JonesAdhar C Manna
May 29, 2013·FEMS Microbiology Ecology·Lee HudekM Leigh Ackland
Dec 3, 2011·FEMS Microbiology Letters·Georgina C DowdCormac G M Gahan
Nov 5, 2014·PLoS Biology·Benjamin A GilstonThomas V O'Halloran
Aug 29, 2006·PLoS Pathogens·David B FriedmanEric P Skaar
May 3, 2014·Journal of Biochemistry·Makoto NakakidoKouhei Tsumoto
Jul 27, 2005·Molecular Plant-microbe Interactions : MPMI·Dong-Jie TangJi-Liang Tang
Feb 13, 2018·Molecular Microbiology·Clémentine FojcikElise Borezée-Durant
Oct 9, 2012·Journal of Bacteriology·Marie-Christin PawlikUlrich Vogel
May 22, 2013·Infection and Immunity·Bryan TroxellX Frank Yang
Jul 20, 2007·Dalton Transactions : an International Journal of Inorganic Chemistry·David P Giedroc, Alphonse I Arunkumar
Nov 4, 2011·Seminars in Immunopathology·James E Cassat, Eric P Skaar
Apr 12, 2014·Metallomics : Integrated Biometal Science·Sangyong Choi, Amanda J Bird
May 13, 2014·Current Microbiology·Xiangyu Yao, Chung-Dar Lu
Oct 3, 2003·Microbiology·Michail H KaravolosSimon J Foster
Feb 26, 2020·Biomolecules·Mohammad Azam AnsariSiddapura Ramachandrappa Niranjana
Apr 21, 2007·Journal of Medical Microbiology·Joshua D CockfieldJodi A Lindsay
Nov 12, 2002·Journal of Bacteriology·Ahmed GaballaJohn D Helmann
Jun 3, 2009·Microbiology and Molecular Biology Reviews : MMBR·Greg A Somerville, Richard A Proctor
Dec 28, 2007·Applied Physics Letters·K M ReddyAlex Punnoose
Sep 18, 2004·Journal of Bacteriology·Laura I KatonaJorge L Benach
Mar 9, 2018·Frontiers in Microbiology·Wenfeng LiuClaire Morvan
Aug 2, 2018·Biochemical Society Transactions·Alevtina MikhaylinaClaudia A Blindauer
Oct 30, 2020·BMC Microbiology·Laura Vinué, David C Hooper

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacterial Transport Proteins

Bacterial transport proteins facilitate active and passive transport of small molecules and solutes across the bacterial membrane. Here is the latest research.

Bacterial Transport Proteins (ASM)

Bacterial transport proteins facilitate active and passive transport of small molecules and solutes across the bacterial membrane. Here is the latest research.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.