Zwitterionic near-infrared fluorophore for targeted photothermal cancer therapy.

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Wonbong LimHoon Hyun

Abstract

Precise photothermal cancer therapy still relies on the development of multifunctional theranostic agents to integrate tumor-specific targeting, imaging, and therapy. In this study, we identified the zwitterionic near-infrared (NIR) fluorophore ZW800-Cl, an analog of the well-known ZW800-1, and found that it preferentially accumulated in tumors in various xenograft models. We have demonstrated that the optical and physicochemical properties of ZW800-Cl are similar to those of ZW800-1, but it has a unique tumor targetability. Since ZW800-Cl showed binding selectivity to cancer cells in vitro, it could be specifically targeted to xenograft models of multiple tumor types, including MCF-7, NCI-H460, and HT-29. The in vivo results of photothermal cancer therapy indicated that the xenograft tumors could be effectively ablated by the combination of ZW800-Cl and an 808 nm laser irradiation. In this regard, our finding may provide a new approach for developing multifunctional cancer theranostic agents, setting them apart from conventional nanoparticles based on inorganic and polymeric materials. Therefore, ZW800-Cl may hold promise as a multifunctional theranostic agent for tumor-targeted imaging and effective photothermal cancer therapy.

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Citations

Feb 27, 2021·Clinical and Translational Medicine·Minghai ZhangYu Wang
Aug 17, 2021·Methods and Applications in Fluorescence·Hazel L Stewart, David J S Birch

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Methods Mentioned

BETA
fluorescence imaging
gel filtration
gel-filtration
xenograft

Software Mentioned

Elements Basic Research
Prism
ImageJ
NIS
JChem

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