ZYG11A serves as an oncogene in non-small cell lung cancer and influences CCNE1 expression

Oncotarget
Xin WangBinhui Ren

Abstract

By analyzing The Cancer Genome Atlas (TCGA) database, we identified ZYG11A as a potential oncogene. We determined the expression of ZYG11A in NSCLC tissues and explored its clinical significance. And also evaluated the effects of ZYG11A on NSCLC cell proliferation, migration, and invasion both in vitro and in vivo. Our results show that ZYG11A is hyper-expressed in NSCLC tissues compared to adjacent normal tissues, and increased expression of ZYG11A is associated with a poor prognosis (HR: 2.489, 95%CI: 1.248-4.963, p = 0.010). ZYG11A knockdown induces cell cycle arrest and inhibits proliferation, migration, and invasion of NSCLC cells. ZYG11A knockdown also results in decreased expression of CCNE1. Over-expression of CCNE1 in cells with ZYG11A knockdown restores their oncogenic activities. Our data suggest that ZYG11A may serve as a novel oncogene promoting tumorigenicity of NSCLC cells by inducing cell cycle alterations and increasing CCNE1 expression.

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Citations

Jul 4, 2017·Biochemical and Biophysical Research Communications·Quanli ZhangBinhui Ren
Mar 30, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Run ShiLin Xu
Apr 24, 2016·Oncotarget·Siwei WangLin Xu
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Nov 20, 2016·Journal of Ovarian Research·Qi SunBinhui Ren
Dec 16, 2020·Molecular and Cellular Endocrinology·Chutima CharoensukPa-Thai Yenchitsomanus
Jul 6, 2021·Frontiers in Endocrinology·Laris AchlaugIlan Bruchim

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Methods Mentioned

BETA
flow cytometry
xenograft
RNA-seq
transfection
surgical resection

Software Mentioned

DAVID Bioinformatics Resources
Editplus®
Google Scholar
genomicMatrix
SPSS Statistics
cBioPortal
tile

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